Drug Response DNA Test – Interpretation Guide

Drug Response DNA Test – Interpretation Guide

DRUG RESPONSE DNA TEST

  • Drug Response or Pharmacogenetics Screening (PGx) DNA Test is a first step into the new world of Personalized Medicine. The U.S. Department of Health & Human Services (HHS) created the Personalized Health Care Initiative to “improve the safety, quality, and effectiveness of healthcare for every patient in the US. By using ‘genomics,’ or the identification of genes and how they relate to treatment, personalized health care will enable medicine to be tailored to each person’s needs.”
  • The primary goal is to enable the physician and patient with information to better understand how their specific gene families interact and impact a specific drug response.
  • Our Pharmacogenetics tests can provide the physician with additional information to mitigate the patient’s adverse response to drug therapies.
  • Pharmacogenetics tests can provide predictive indicators that can assist the physician to determine the risk of thrombosis or prothrombin deficiency and help determine the therapeutic value of commonly used drugs for cardiovascular conditions.
  • For psych, the test can help physicians predict patient response to neuroactive drug therapy. These tests incorporate a broad suite of antidepressants, antipsychotics, and anxiolytics.
  • Pharmacogenetics is also valuable in helping physicians to understand their patients’ responses to a drug proactively and ideally eliminate the adverse reactions that often come with these types of drugs.
  • Pharmacogenetics test offers an in-depth analysis of a patient’s cytochrome P450 superfamily (CYP450), which is responsible for drug metabolism and biotransformation. This will allow physicians to fine-tune drug dosage for greatest efficacy and safety without time-consuming and potentially dangerous trial-and-error. This can result in fewer patient visits, faster appropriate dosages, and higher levels of safety.

Who Can Benefit?

Prescribing medications to a patient can be difficult. Everyone’s DNA is set up differently. Take the difficult guesswork out of prescribing medications and look for the following qualifying attributes:

  • Patients who are currently taking opioids to manage pain
  • Patients who are taking cardiovascular medication to manage cardiovascular problems
  • Patients for whom genetic testing is recommended or medically necessary
  • Patients with a list of side effects from their current medications
  • Patients that need to be put on strong medication, and you are unsure how to start their dosing
  • Patients who are currently taking 2 or more chronic medications

Pharmacogenetics test offers the following disease state predispositions:

  • Hyperuricemia and Gout
  • Type III Hyperlipoproteinemia
  • Platelet Hyperactivity
  • Thrombophilia
  • Hyperhomocysteinemia – Thrombosis
  • Alcohol-Related Co-morbidities
  • Hyperhomocysteinemia – Depression
  • Antipsychotic-Induced Tardive Dyskinesia
  • Antipsychotic-Induced Hyperprolactinemia
  • Hyperlipidemia/Atherosclerotic Cardiovascular Disease
  • Sodium Channels Function and Bipolar Disorder
  • Calcium Channels Function and Bipolar Disorder
  • Nitric Oxide Production and Coronary Artery Disease
  • Antipsychotic-Induced Weight Gain

Two types of panels:

  • COMP- cover 17 genes/SNPs
  • PLUS- cover 44 genes/SNPs

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