*Please note that the lab fee for this test is a separate cost.
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving both upper motor neurons (UMN) and lower motor neurons (LMN). UMN signs include hyperreflexia, extensor plantar response, increased muscle tone, and weakness in a topographic representation. LMN signs include weakness, muscle wasting, hyporeflexia, muscle cramps, and fasciculations. Initial presentation varies.
Affected individuals typically present with either asymmetric focal weakness of the extremities (stumbling or poor handgrip) or bulbar findings (dysarthria, dysphagia). Other findings may include muscle fasciculations, muscle cramps, and labile affect, but not necessarily mood.
Regardless of initial symptoms, atrophy and weakness eventually affect other muscles. The mean age of onset is 56 years in individuals with no known family history and 46 years in individuals with more than one affected family member (familial ALS or FALS).
The average disease duration is about three years but can vary significantly. Death usually results from compromise of the respiratory muscles.
Our ALS DNA Kit tests 36 gene variations involved in nine key biological processes, which are all key factors in the onset of chronic disease.
Deletion/Duplication Testing (MLPA/qPCR)
Turnaround Time: 15 Business Days
What's inside the Kit:
Buccal Swab Vial (sealed silver pouch)
Sample collection envelope (with Activation code)
Activation Code Sticker (to be placed on the vial)
'HOW TO' instructional guide
Coupon code for your next purchase
Prepaid return envelope
NOTE: We currently do not offer this service in New York.